TABLE 1

Metabolism of wortmannin by unfractionated mouse tissue homogenates


Tissue

Rate of Metabolite Productiona

Rate Relative to Liver
nmol/min/mg protein
Liver 0.18 ± 0.01b 1.00
Kidney 0.06 ± 0.01 0.35
Lung 0.03 ± 0 0.16
Brain N.D.c
Red blood cells
0.01 ± 0.00
0.03
  • a Both NADPH and NADH were included as cofactors

  • b Mean ± S.D

  • c N.D., no detectable metabolite in reaction mixture