TABLE 1

Pharmacokinetic data of berberine in rat blood, liver, and bile dialysate after i.v. administration of berberine (10 or 20 mg kg-1) alone and with CsA (20 mg kg-1) Data are expressed as means ± S.E.M. from six individual experiments for each treatment group.


Treatment

AUC

CL

t1/2

AUCliver or bile/AUCblood
min μg ml-1 ml kg-1 min-1 min
Blood
   Berberine, 10 mg kg-1 265.4 ± 44.0 43.7 ± 7.6 15.5 ± 3.2
      +CsA, 20 mg kg-1 306.4 ± 55.5 37.7 ± 5.8 16.8 ± 5.2
   Berberine, 20 mg kg-1 506.6 ± 39.3a 40.9 ± 3.7 33.6 ± 4.3a
      +CsA, 20 mg kg-1 471.6 ± 55.9 45.5 ± 5.3 29.0 ± 4.9
Liver
   Berberine, 20 mg kg-1 84.6 ± 6.4 0.18 ± 0.03
      +CsA, 20 mg kg-1 30.7 ± 4.0b 0.07 ± 0.002b
Bile
   Berberine, 10 mg kg-1 1470 ± 134 6.6 ± 1.6
      +CsA, 20 mg kg-1 14.9 ± 3.9a 0.05 ± 0.01a
   Berberine, 20 mg kg-1 3575 ± 165a 7.4 ± 0.9
      +CsA, 20 mg kg-1
109.1 ± 27.8b


0.3 ± 0.1b
  • a p < 0.05 compared with the 10 mg kg-1 berberine-alone group

  • b p < 0.05 compared with the 20 mg kg-1 berberine-alone group