Pharmacokinetic data of berberine in rat blood, liver, and bile dialysate after i.v. administration of berberine (10 mg kg-1) alone and with quinidine (10 mg kg-1), SKF-525A (10 mg kg-1), or probenecid (100 mg kg-1) Data are expressed as means ± S.E.M. from six individual experiments for each treatment group.
Treatment | AUC | CL | t1/2 | AUCliver or bile/AUCblood |
|---|---|---|---|---|
| min μg ml-1 | ml kg-1 min-1 | min | ||
| Blood | ||||
| Berberine, 10 mg kg-1 | 265.4 ± 44.0 | 43.7 ± 7.6 | 15.5 ± 3.2 | |
| +Quinidine, 10 mg kg-1 | 342.6 ± 29.6 | 30.8 ± 3.8 | 23.2 ± 3.6 | |
| +SKF-525A, 10 mg kg-1 | 322.6 ± 42.6 | 32.5 ± 3.9 | 18.9 ± 3.8 | |
| +Probenecid, 100 mg kg-1 | 167.8 ± 18.3 | 56.6 ± 4.9a | 21.6 ± 3.7 | |
| Liver | ||||
| Berberine, 10 mg kg-1 | 47.4 ± 4.5 | 0.18 ± 0.03 | ||
| +SKF-525A, 10 mg kg-1 | 126.8 ± 14.9a | 0.56 ± 0.05a | ||
| Bile | ||||
| Berberine, 10 mg kg-1 | 1470 ± 134 | 6.6 ± 1.6 | ||
| +Quinidine, 10 mg kg-1 | n.c | n.c. | ||
| +SKF-525A, 10 mg kg-1 | 3526 ± 163a | 11.6 ± 1.5a | ||
| +Probenecid, 100 mg kg-1 | 1376 ± 147 |
|
| 8.8 ± 1.3 |
n.c., not calculable.
↵ a p < 0.05 compared with the 10 mg kg-1 berberine-alone group