The IC50 values for tea catechins and bioflavonoids in inhibiting the O-methylation of 2-OH-E2 and 4-OH-E2 catzlyzed by human liver cytosolic COMT
Inhibitor | Cytosol Sample | IC50 value | ||
|---|---|---|---|---|
| 2-OH-E2 | 4-OH-E2 | |||
| μM | ||||
| Catechin | Liver HL7C | 15 | 7 | |
| Liver HL8C | 17 | 7 | ||
| Liver HL9C | 14 | 6 | ||
| Epicatechin | Liver HL1C | 49 | 18 | |
| Liver HL2C | 59 | 16 | ||
| Liver HL3C | 65 | 10 | ||
| Liver HL4C | 49 | 16 | ||
| Liver HL6C | 44 | 15 | ||
| Epigallocatechin gallate | Liver HL8C | 0.07 | 0.46 | |
| (EGCG) | Liver HL9C | 0.04 | 0.37 | |
| Quercetin | Liver HL8C | 1.5 | 1.2 | |
| Liver HL9C | 0.9 | 0.5 | ||
| Fisetin | Liver HL8C | 4.5 | 4.2 | |
|
| Liver HL9C | 3.3 | 2.6 | |