TABLE 4

Brain-to-plasma concentration or AUC ratio of several H1-antagonists after i.v. administration to mdr1a/b(-/-) mice

H1-Antagonist
Brain-to-Plasma Concentration Ratio
Brain-to-Plasma AUC Ratio
Referencea
Deslortadine 14.1b 1
Diphenhydramine 9.42b 1
Hydroxyzine 4.75b 1
Triprolidine 3.60b 1
Loratadine 3.30b 1
Ebastine 1.02c 3
Epinastine 0.70b
Fexofenadine 0.33c 2
Carebastine 0.17c 3
Cetirizine
0.08b
1

  • ↵ a 1, Chen et al. (2002); 2, Cvetkovic et al. (1999); 3, Tamai et al. (2000a)

  • ↵ b Data were obtained from mdr1a/b(-/-) mice

  • ↵ c Data were obtained from mdr1a(-/-) mice