Change in biological parameters in DSS-colitis rats
Rats were given 3% DSS in drinking water for 7 days or a 4 mg/kg intraperitoneal dose of LPS. The sampling was performed on the 7th day, or 8 and 24 h after the injection of LPS. MPO activity of homogenate from colon mucosa, endotoxin in serum from portal vein, and serum ALT activity were determined. Results are means ± S.E. of four (control, LPS) or eight (DSS) rats.
Control | DSS | LPS (8 h) | LPS (24 h) | |
|---|---|---|---|---|
| Body weight (g) | 249 ± 7 | 239 ± 7 | 236 ± 6 | 239 ± 10 |
| Liver weight (g) | 9.9 ± 0.5 | 9.0 ± 0.4 | 8.8 ± 0.5 | 10.7 ± 0.7 |
| ALT (IU/l) | 8.2 ± 0.6 | 6.2 ± 0.9 | 22.9 ± 5.6a | 31.5 ± 11.9a |
| MPO (U/g) | 5.1 ± 0.2 | 45.3 ± 11.7a | —b | — |
| Endotoxin (pg/ml) | 6.6 ± 1.5 | 40.2 ± 9.0a | — | — |