TABLE 3

Effect of MTZ, ETM, and KTZ on the sulfoxidation of ABZ by sheep lung microsomes Data are the mean (±S.D.) of 12 determinations.

Incubated Substrates
(total) ABZSO
(-) ABZSO
(+) ABZSO
Ratio (±)a
% Inhibition
(total) ABZSO
(-) ABZSO
nmol · min-1 · mg-1
ABZ (control) 0.20 ± 0.06 0.09 ± 0.02 0.11 ± 0.06 1.38 ± 0.88 N.A. N.A.
ABZ + MTZ (100 μM) 0.22 ± 0.05 0.11 ± 0.08 0.11 ± 0.06 1.22 ± 0.85 N.A. N.A.
ABZ (control) 0.21 ± 0.09 0.09 ± 0.05 0.12 ± 0.08 1.88 ± 1.53 N.A. N.A.
ABZ + ETM (500 μM) 0.14 ± 0.05* 0.03 ± 0.01** 0.11 ± 0.05 4.33 ± 2.62* 33 67
ABZ + KTZ (200 μM)
0.11 ± 0.06**
0.02 ± 0.00***
0.09 ± 0.06
5.76 ± 3.50**
48
78

  • N.A., not applicable.

    Values are significantly different from those observed in control incubations at *p < 0.05, **p < 0.01, and ***p < 0.001.

  • ↵ a The mean (±S.D.) ratio between the rate of (+) ABZSO and (-) ABZSO production found in each individual assay