Microsomes | P450 Enzymes | Km | Vmax | Vmax/Km |
---|---|---|---|---|
μM | pmol/min/mg protein | |||
Untreated rat | CYP3A1/2 | 5.6 | 52 | 9.1 |
Minipig | CYP3A29 | 3.5 | 52 | 15 |
8.1 (males) | 23 (males) | 2.9 | ||
Regular pig | CYP3A29 | 5.1 (females) | 21 (females) | 4.0 |
Humansa | CYP3A3/4 | 3.9-6.9 | 11.8-23 | 0.3-16.2 |
↵ a Interval of kinetic constants from two male human microsmes