Inhibition of diazepam metabolism by omeprazole in rat liver microsomes and rat hepatocytes
Metabolic Pathway | Microsome Ki | Hepatocyte Ki |
|---|---|---|
| μM | μM | |
| 4′-HDZ | 7.2 ± 2.4 | 7.8 ± 2.3 |
| 3-HDZ | 19.7 ± 2.7 | 21.9 ± 9.1 |
| NDZ | 32.9 ± 6.0 | 46.2 ± 22.3 |
| Metabolite formation weighted Ki | 12.4 ± 2.4 | 15.8 ± 5.1 |
| Depletion Ki | 16.2 ± 2.6 | 7.3 ± 2.2 |
Data represent a mean ± S.D. (n = 4).