Reproducibility of CYP3A inhibition by star fruit Values are presented as mean ± S.D. of triplicate assays. The amount of fruit juice used in assays was 25 μl (5.0%, v/v). The control activity of midazolam 1′-hydroxylation by human liver microsomes determined in the absence of fruit juice was 1.63 nmol/min/mg protein.
Purchase Date of Star Fruit | Shop | Preparation Date of Juice | Residual Activity |
|---|---|---|---|
| (%) | |||
| November 19, 2003 | A | November 20, 2003 | 0.1 ± 0.0 |
| December 18, 2003 | A | December 18, 2003 | 0.3 ± 0.1 |
| January 27, 2004 | A | February 3, 2004 | 0.4 ± 0.1 |
| January 27, 2004 | B | February 3, 2004 | 0.3 ± 0.1 |