TABLE 2

Mean recovery of radioactivity in urine and feces after a single oral dose of [14C]capravirine to group A male volunteers (n = 5) and multiple oral doses of ritonavir followed by a single oral dose of [14C]capravirine to group B male volunteers (n = 5)

Matrix
Interval
Percentage of Dose Recovered
Group A
Group B
h
Urine 0—4 12.3 ± 1.9 4.6 ± 1.3
4—8 9.8 ± 1.4 6.2 ± 1.6
8—12 4.3 ± 1.0 4.9 ± 1.4
12—24 6.6 ± 0.9 11.5 ± 2.2
24—36 4.5 ± 0.9 6.7 ± 2.0
36—48 2.8 ± 0.9 3.6 ± 1.1
48—72 2.7 ± 1.3 3.1 ± 0.8
72—96 0.8 ± 0.8 0.7 ± 0.7
96—120 0.3 ± 0.4 0.2 ± 0.3
120—144 0.1 ± 0.2 N.D.
144—168 N.D.a N.D.
0—168 44.3 ± 3.2 41.5 ± 6.1
Feces 0—24 8.1 ± 8.3 2.5 ± 4.2
24—48 15.4 ± 13.9 18.6 ± 10.7
48—72 5.2 ± 5.3 6.8 ± 8.3
72—96 8.5 ± 11.1 6.5 ± 7.3
96—120 4.2 ± 8.4 0.9 ± 1.3
120—144 0.1 ± 0.1 0.6 ± 1.0
144—168 0.5 ± 0.6 1.4 ± 3.1
0—168 42.0 ± 18.0 37.4 ± 17.0
Urine and Feces
0—168
86.3 ± 16.4
79.0 ± 23.1

  • ↵ a N.D., not detected