Quantitative evaluation of various methods for predicting human clearance from preclinical pharmacokinetic data Data are expressed as median values for n = 103 observations.
Method | Fold Variance | Variance | Absolute Variance |
|---|---|---|---|
| ml/min/kg | ml/min/kg | ||
| Three-species allometry | 1.12 | 0.33 | 2.31 |
| Rat and dog allometry | 1.39 | 1.14 | 3.21 |
| Rat and monkey allometry | 0.90 | -0.13 | 2.89 |
| LBF rat | 1.52 | 0.77 | 2.41 |
| LBF dog | 1.61 | 1.60 | 2.70 |
| LBF monkey | 1.03 | 0.02 | 1.23 |
| LBF rat + LBF dog | 1.81 | 1.53 | 3.21 |
| LBF rat + LBF monkey | 1.48 | 0.55 | 2.62 |
| LBF dog + LBF monkey | 1.49 | 0.75 | 2.52 |