Quantitative accuracy of various methods for predicting human volume of distribution from preclinical pharmacokinetic data Data are expressed as median values for n = 103 observations.
Method | Fold Variance | Variance | Absolute Variance |
|---|---|---|---|
| l/kg | l/kg | ||
| Three-species allometry | 1.03 | 0.02 | 0.27 |
| Rat and dog allometry | 1.15 | 0.05 | 0.31 |
| Rat and monkey allometry | 0.25 | -0.27 | 0.43 |
| Dog and monkey allometry | 0.32 | -0.33 | 0.36 |
| Rat volume | 1.42 | 0.15 | 0.43 |
| Dog volume | 1.33 | 0.09 | 0.34 |
| Monkey volume | 1.00 | 0.00 | 0.23 |
| Average of rat and dog | 1.53 | 0.21 | 0.34 |
| Average of rat and monkey | 1.34 | 0.15 | 0.29 |
| Average of dog and monkey | 1.34 | 0.08 | 0.26 |