Quantitative accuracy of various methods for predicting human mean residence time from preclinical pharmacokinetic data Data are expressed as median values for n = 103 observations.
Method | Fold Variance | Variance | Absolute Variance |
|---|---|---|---|
| min | min | ||
| Three-species allometry | 0.960 | -4.95 | 140 |
| Rat and dog allometry | 0.837 | -18.2 | 154 |
| Rat and monkey allometry | 0.355 | -107 | 154 |
| Dog and monkey allometry | 0.078 | -113 | 206 |
| Rat volume and LBF | 0.931 | -11.3 | 172 |
| Dog volume and LBF | 0.797 | -23.5 | 157 |
| Monkey volume and LBF | 1.09 | 11.0 | 104 |
LBF, liver blood flow.