Inhibition of CYP2B6-catalyzed bupropion hydroxylation by various substances in human liver microsomes
Inhibitor | IC50 | Inhibition (% of Control) at the Highest Concentration Used |
|---|---|---|
| μM | ||
| Ticlopidine | 0.32 | 100 (1) |
| ThioTEPA | 1.75 | 100 (100) |
| Tranylcypromine | 3.1 | 90 (100) |
| Ketoconazole | 3.5 | 70 (100) |
| Metyrapone | 4.14 | 100(1000) |
| Xanthate C8 | 6.93 | 100(1000) |
| Benzyl-isothiocyanate | 8.59 | 100 (100) |
| Retinol | 17.0 | 70 (100) |
| Deramciclane | 63.5 | 58 (100) |
| Troglitazone | 88.2 | 55 (100) |
| Ethinylestradiol | 100 | 50 (100) |