Inhibition assay results Values of the present study are mean ± S.E.
Substrate | Inhibitor | Mode of Inhibition | Ki Total | Ki Unbound | |
|---|---|---|---|---|---|
| μM | |||||
| Diclofenac | Tolbutamide | Competitive | 59 ± 13 | 59 | |
| Diclofenac | Ibuprofen | Competitive | 30 ± 2.3 | 30 | |
| Diclofenac | Fluvastatin | Noncompetitive | 0.20 ± 0.015 | 0.12 | |
| Tolbutamide | Diclofenac | Competitive | 6.0 ± 2.0 | 5.2 | |
| Ibuprofen | Diclofenac | Competitive | 3.0 ± 0.2 | 2.6 | |
| Fluvastatin | Diclofenac | Competitive | 16.0 ± 5.4 | 13.8 | |