TABLE 2

Net Exposure Following an Oral Dose (250 mg/kg) of formulated or crystalline DIM in Mice

AUC (0-24 h)a
AUC Ratiob
 BR-DIM
Crystalline
Plasma 25.4 19.0 1.34
Liver 207 129 1.60
Kidney 93.2 61.8 1.51
Lung 104 70.5 1.48
Heart 79.8 54.2 1.47
Brainc
25.5
19.0
1.34

  • ↵ a Values are μg · h/(ml or g), calculated using mean data (Figs. 3 and 4) and the linear trapezoidal rule in WinNonlin (v3.2; Pharsight, Mountain View, CA)

  • ↵ b Formulated/crystalline AUC ratio

  • ↵ c Brain AUC values calculated from 0 to 6 h