TABLE 3

Final estimated PBPK model parameters


Parameter

Estimated Value

CV%a
ka (h-1) 2.38 16
F1 0.0170 9.7
F2 0.0274 9.6
Cl (ml/h) 7.18 8.1
ClD (ml/h) 2.21 41
σ1 0.257 24
σ2
0.187
11
  • a CV% of the estimate, not reflective of inter-animal variability