Inhibitor | 5′-DFCR Formation | IC50 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Microsomes + Cytosol | Microsomes | Cytosol | Microsomes + Cytosol | Microsomes | Cytosol | ||||||
μM | pmol/min/mg protein | nM | |||||||||
None | 3.0 (100) | 6.2 (100) | 1.9 (100) | ||||||||
BNPP | 0.1 | 2.4 (78) | 5.7 (92) | 1.5 (82) | 609 | 1064 | 381 | ||||
1 | 1.1 (35) | 3.3 (52) | 0.6 (34) | ||||||||
10 | 0.0 (0) | 0.5 (7) | 0.0 (0) | ||||||||
DFP | 0.05 | 2.8 (94) | 5.6 (90) | 1.4 (74) | 158 | 115 | 77 | ||||
0.1 | 2.0 (67) | 3.5 (56) | 0.7 (38) | ||||||||
| 1 | 0.0 (0) | 1.2 (18) | 0.4 (23) |
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