Parameters | (S)-Ketamine | (R)-Ketamine | (S)-Norketamine | (R)-Norketamine | Dehydronorketamine 1 | Dehydronorketamine 2 |
---|---|---|---|---|---|---|
Control | ||||||
k (min-1)a | 0.0976 (34) | 0.0964 (35) | 0.0332 (11) | 0.0279 (15) | 0.375 (72) | 0.194 (166) |
ke (min-1)b | 0.0202 (15) | 0.0189 (15) | 0.0297 (11) | 0.0495 (15) | 0.518 (73) | 0.550 (167) |
Cl/F (l · h-1 · kg-1)c | 7.39 (7.1) | 6.84 (7.2) | 6.60 (5.2) | 12.1 (6.2) | 16.8 (5.5) | 18.7 (11) |
V/F (l · kg-1)c | 6.08 (15) | 6.04 (15) | 3.70 (11) | 4.09 (15) | 0.540 (72) | 0.566 (166) |
PCM | ||||||
k (min-1) | 0.195 (54) | 0.153 (38) | 0.0746 (13) | 0.0676 (15) | 0.0134 (28) | 0.0171 (44) |
ke (min-1) | 0.0124 (14) | 0.0127 (12) | 0.0235 (16) | 0.0349 (16) | 0.0398 (31) | 0.116 (45) |
Cl/F (l · h-1 · kg-1) | 5.05 (7.2) | 5.00 (6.3) | 1.59 (6.7) | 2.58 (6.3) | 7.66 (9.6) | 10.8 (7.6) |
V/F (l · kg-1) | 6.80 (11) | 6.56 (11) | 1.13 (13) | 1.23 (15) | 3.21 (28) | 1.55 (43) |