Pharmacokinetic parameters
Cmax | tmax | AUC0-48 h | AUCtotal | ke | t1/2 | |
|---|---|---|---|---|---|---|
| ng/ml | h | ng/ml · h−1 | ng/ml · h−1 | h−1 | h | |
| Achiral Results | ||||||
| MDMA | 208.7 ± 17.1 | 1.6 ± 0.4 | 3108.5 ± 329.8 | 3223.4 ± 425.5 | 0.07 ± 0.03 | 11.8 ± 4.4 |
| MDA | 13.0 ± 2.3 | 6.6 ± 1.9 | 308.4 ± 73.1 | 361.8 ± 90.9 | 0.04 ± 0.01 | 17.7 ± 6.2 |
| HMMA | 163.8 ± 71.4 | 2.8 ± 0.8 | 2293.2 ± 881.5 | 2293.2 ± 881.5 | 0.07 ± 0.01 | 10.4 ± 2.4 |
| Chiral Results | ||||||
| (R)-MDMA | 116.7 ± 14.3 | 3.5 ± 2.1 | 2158.8 ± 297.5 | 2292.8 ± 490.8 | 0.06 ± 0.04 | 14.8 ± 9.2 |
| (S)-MDMA | 88.8 ± 17.0 | 1.9 ± 0.5 | 773.0 ± 83.3 | 773.0 ± 83.3 | 0.16 ± 0.07 | 4.8 ± 1.7 |
| (1)-MDA | 1.7 ± 0.6 | 15.9 ± 10.5 | 52.6 ± 22.0 | 52.6 ± 22.0 | 0.05 ± 0.03 | 18.3 ± 10.6 |
| (2)-MDA | 7.7 ± 3.9 | 6.7 ± 2.5 | 130.6 ± 43.4 | 145.2 ± 37.2 | 0.07 ± 0.04 | 11.9 ± 5.4 |
| (R)-HHMA | 38.9 ± 12.4 | 2.4 ± 1.9 | 653.5 ± 22.2 | 1104.3 ± 362.2 | 0.06 ± 0.05 | 42.6 ± 56.3 |
| (S)-HHMA | 90.9 ± 38.8 | 2.3 ± 1.8 | 999.2 ± 459.0 | 1099.7 ± 538.7 | 0.10 ± 0.04 | 7.9 ± 2.7 |
| (R)-HMMA | 65.0 ± 26.1 | 2.9 ± 0.7 | 868.9 ± 453.3 | 946.2 ± 501.3 | 0.06 ± 0.02 | 13.5 ± 4.1 |
| (S)-HMMA | 62.1 ± 21.6 | 2.6 ± 0.6 | 585.3 ± 216.6 | 588.2 ± 216.0 | 0.12 ± 0.02 | 5.9 ± 1.0 |
(1)-MDA, first eluted MDA enantiomer; (2)-MDA, second eluted MDA enantiomer.