Inducing agent properties
Data were compiled from Gilman et al. (1990); Blumberg et al. (1998); Zhang et al. (1998); Moore et al. (2000a,b); Dussault et al. (2001); and Morello et al. (2003).
Agent | F | Species | PXR Activation | ||
|---|---|---|---|---|---|
| hPXR | mPXR | ||||
| Dexamethasone | 78% | Human | 0 | ++ | |
| Nelfinavir | ND | 0 | 0 | ||
| Nifedipine | 50% | Human | ++ | + | |
| PCN | ND | 0 | +++ | ||
| Rifampin | 76% | Rat | +++ | 0/+ | |
| St. John's wort | ND | ++ | ND | ||
| Tamoxifen | >95% | Human | + | 0 | |
F, oral bioavailability; hPXR, human PXR; mPXR, mouse PXR; 0, no activity; +, some activity; ++, moderate activity; +++, strong activity; ND, no data.