Rifampin concentrations in plasma and target tissues
Mice (n = 4 per time point) were treated with 250 mg/kg rifampin by oral gavage with a single dose (day 1) or with chronic daily administration (day 5). Rifampin concentrations in plasma and tissues (mean ± S.D.) were determined by high-performance liquid chromatography/mass spectometry.
Plasma | Intestine | Liver | Brain | |||
|---|---|---|---|---|---|---|
| μg/ml | μg/g | |||||
| Day 1 | ||||||
| 2 h | 168.6 ± 37.8 | 94.5 ± 12.6 | 54.3 ± 23.2 | 1.3 ± 0.5 | ||
| 24 h | 26.8 ± 5.0 | 44.1 ± 14.7 | 211.4 ± 23.2 | 6.0 ± 2.6 | ||
| Day 5 | ||||||
| 2 h | 157.3 ± 92.0 | 383.5 ± 156.1 | 143.8 ± 57.1 | 10.5 ± 1.4 | ||
| 24 h | 21.1 ± 9.1 | 35.4 ± 15.0 | 63.0 ± 13.5 | 4.0 ± 0.9 | ||