Similarity of CYP1 family substrate recognition sites Substrate recognition sites (SRSs) are as described for family 2 P450s by Gotoh (1992), based upon alignment with CYP101, as modified for family 1 P450 alignments with CYP2C5 (Lewis et al., 2003).
CYP1B1 Substrate Recognition Sites | Identical Sequence | ||||
|---|---|---|---|---|---|
| Cyp1b1 | CYP1A1 | CYP1A2 | |||
| % | |||||
| SRS-1 (116–139) | 89 | 37 | 21 | ||
| RPAFASFRVVSGGRSMAFGHYSE | |||||
| SRS-2 (224–236) | 100 | 46 | 30 | ||
| LLSHNEEFGRTVG | |||||
| SRS-3 (259–263) | 80 | 20 | 20 | ||
| REFEQ | |||||
| SRS-4 (330–343) | 100 | 43 | 36 | ||
| ATITDIFGASQDTL | |||||
| SRS-5 (392–401) | 90 | 90 | 80 | ||
| SSFVPVTIPH | |||||
| SRS-6 (503–508) | 90 | 60 | 50 | ||
| MNFSYGLTIK |
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