Cimetidine | Ranitidine | Famotidine | |||||||
---|---|---|---|---|---|---|---|---|---|
Control | +Probenecid | Control | +Probenecid | Control | +Probenecid | ||||
Cp (μM) | 3.71 ± 1.20 | 2.97 ± 0.15 | 2.65 ± 1.25 | 2.11 ± 0.18 | 3.47 ± 1.22 | 2.79 ± 0.03 | |||
Cp,fu (μM) | 2.25 ± 0.60 | 1.89 ± 0.11 | 1.72 ± 0.49 | 1.52 ± 0.06 | 2.01 ± 0.72 | 1.54 ± 0.18 | |||
CCSF (nM) | 39.1 ± 19.8 | 116 ± 17** | 25.9 ± 12.0 | 97.1 ± 5.2*** | 23.1 ± 9.2 | 43.9 ± 4.1* | |||
Cbrain (nM) | 96.5 ± 27.1 | 99.9 ± 12.5 | 85.7 ± 33.8 | 83.9 ± 10.9 | 106 ± 30 | 102 ± 18 | |||
CCSF/Cp,fu ratio | 0.0166 ± 0.005 | 0.0615 ± 0.0121** | 0.0147 ± 0.0046 | 0.0639 ± 0.0046*** | 0.0114 ± 0.0027 | 0.0289 ± 0.0057** |
Cp, total plasma concentration; Cp,fu, unbound plasma concentration; CCSF, CSF concentration; Cbrain, brain concentration.
*p < 0.05, **p < 0.01, and ***p < 0.001, significantly different from control rats (unpaired t test).