Microsomes from | GA Concentration | n | Percentage Change in NNAL Quantity | Percentage of (R)-NNAL | ||
---|---|---|---|---|---|---|
without GA | with GA | |||||
μM | ||||||
Human liver | 0.1 | 4 | −10 ± 8 | 80 ± 3 | 83 ± 3a | |
10 | 8 | −39 ± 14a | 70 ± 11 | 84 ± 14a | ||
Human placenta | 10 | 6 | −6 ± 12 | 87 ± 4 | 91 ± 3b | |
Human lung | 0.1 | 3 | −1 ± 5 | 86 ± 6 | 86 ± 6 | |
1 | 3 | +12 ± 8 | 85 ± 6 | 87 ± 6 | ||
Rat liverc | 0.1 | 4 | −12 ± 8b | 26 ± 1 | 27 ± 2 | |
10 | 3 | −43 ± 9b | 28 ± 2 | 40 ± 7b | ||
Rat lungc | 0.1 | 4 | −32 ± 10b | 53 ± 8 | 85 ± 4a | |
| 10 | 4 | −50 ± 5a | 49 ± 5 | 86 ± 4a |