Mean (S.D.) pharmacokinetic parameters of total radioactivity and tesaglitazar after i.v. (A) and oral (B) doses of 14C-labeled or nonlabeled tesaglitazar, 1 mg, n = 8
i.v. | Oral | |
|---|---|---|
| Total Radioactivity | ||
| AUC0-192 hab (μmol · h/l) | 16.2 (2.3) | 16.1 (0.6) |
| Tesaglitazar | ||
| AUC0-192hb (μmol · h/l) | 14.9 (2.7) | 14.5 (0.7) |
| CL (l/h) | 0.163 (0.025) | |
| Vss (liters) | 9.1 (1.0) | |
| CLR (l/h) | 0.031 (0.007) | 0.032 (0.003) |
| t (h) | 45 (6) | 46 (7) |
| Cmax (μmol/l) | 0.65 (0.09) | |
| tmaxc (h) | 0.5 (0.5-1.0) | |
| F (%) |
| 103 (4) |