Pharmacokinetic parameters of 4MUS after intravenous infusion in Bcrp1(−/−) and wild-type mice
Results are mean ± S.E. (n = 3-4).
Wild Type | Bcrp1(−/−) | |
|---|---|---|
| Cp (μM) | 10.5 ± 2.2 | 10.4 ± 2.9 |
| Vurine (nmol/min/kg) | 172 ± 28 | 189 ± 17 |
| CLtotal (ml/min/kg) | 22.1 ± 5.1 | 21.9 ± 5.0 |
| CLrenal,p (ml/min/kg) | 20.8 ± 7.3 | 20.8 ± 5.6 |
| CLrenal,k (ml/min/kg) | 8.60 ± 5.43 | 5.70 ± 0.70 |
|
K
p,kidney
| 3.60 ± 1.38 | 3.73 ± 0.59 |
Cp, plasma concentrations at 90 min; Vurine, urinary excretion rate from 60 to 90 min; CLtotal, total clearance; CLrenal,p, renal clearance with respect to circulating plasma; CLrenal,k, renal clearance with respect to the kidney concentration; Kp,kidney, kidney-to-plasma concentration ratio.