Drug | Metabolite | Ratio of Activity of Metabolite to Parent Druga | ||||
---|---|---|---|---|---|---|
5-HT | Noradrenaline | Dopamine | ||||
Amitryptiline | Nortryptiline | 0.07 | 7 | Inactive | ||
Dothiepin | Northiaden | 0.4 | 2.8 | Inactive | ||
Dothiepin | Sulfoxide | Inactive | Inactive | Inactive | ||
Imipramine | Desipramine | 0.06 | 31 | |||
Imipramine | 2-Hydroxyimapramine | 1 | 1 | |||
Clomipramine | Norcloipramine | 0.01 | 15 | |||
Fluoxetine | Norfluoxetine | 1.8 | 0.64 | Inactive | ||
Sibutramine | Desmethylsibutramine | 100 | 7 | |||
Sibutramine | Didesmethylsibutramine | 100 | 6 | |||
Sertraline | Desmethylsertraline | Inactive | Inactive | Inactive | ||
Citaprolam | Desmethylcitalopram | 0.12 | Inactive | Inactive | ||
Amperozide | FG5620 | Inactive |
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↵ a This value is calculated as in vitro potency (e.g., Ki) of parent drug/in vitro potency of metabolite for the target receptor. The entry `inactive' means that the metabolite lacks appreciable affinity for the receptor