TABLE 1

Distribution parameters for pralmorelin in rats estimated from hybrid model (n = 3, estimates ± error)


Tissue

Kp0 a

PS·fb b

k2 b
ml/g tissue ml/h h–1
Muscle 0.147 2.85 ± 3.93 0.509 ± 1.57
Heart 0.401 0.188 ± 0.180 1.22 ± 2.26
Small intestine 0.835 2.84 ± 4.11 0.718 ± 2.03
Lung 1.06 0.786 ± 0.696 0.313 ± 0.746
Kidney 3.82 2.21 ± 1.72 0.749 ± 0.349
Liver
Brain 0.0397 0.0179 ± 0.0150 0.509 ± 0.978
Skin 0.487 1.72 ± 1.23 0.409 ± 0.271
Adipose
0.142
0.337 ± 0.624
0.961 ± 3.34
  • a The average of Kp values at 5, 15, and 30 min

  • b Estimated from a hybrid model using the blood concentration vs. time curve as the input function