Physiological data and estimated parameters of pralmorelin for various tissues in rats
Tissue | Tissue Weight (Vwt)a | Tissue Blood Flowa | CLintb | Kpss c |
|---|---|---|---|---|
| g | ml/h | ml/h | ml/g tissue | |
| Arterial blood | 5.6 | 2394 | ||
| Venous blood | 11.3 | |||
| Muscle | 122 | 450 | ||
| Heart | 1 | 234 | ||
| Small intestine | 11.4 | 450 | ||
| Lung | 2.1 | 2394 | ||
| Kidney | 4 | 552 | 36.9 | |
| Liver | 10 | 708 | 830 | 18.9 |
| Brain | 1.2 | 78 | ||
| Skin | 40 | 348 | ||
| Adipose | 10 | 24 |
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↵ a The volume and blood flow for each tissue were taken from Hosseini-Yeganeh and McLachlan (2002). The tissue volume was converted to tissue weight based on the assumption of the tissue gravity of 1 g/ml
↵ b CLtot is estimated using blood concentration and the renal blood clearance is calculated from the urinary excretion. The extrarenal clearance is assumed as the hepatic blood clearance and calculated using the blood flow. Renal blood clearance is assumed to be equal to the glomerular filtration rate
↵ c Estimated from a hybrid model using the blood concentration vs. time curve as the input function