Assay Description | Saline | 25 μg of LPS i.v. |
---|---|---|
CYP1A1 expression in liver relative to GAPDH (6-h time point) | 1.00 ± 0.39 | 0.069 ± 0.03* |
CYP2B1/2 expression in liver relative to GAPDH (6-h time point) | 2.54 ± 0.63 | 1.18 ± 0.17* |
TNFα expression in liver relative to GAPDH (3-h time point) | 0.38 ± 0.05 | 1.25 ± 0.37* |
CYP2D1/5 expression in liver relative to GAPDH (6-h time point) | 87.80 ± 8.58 | 68.67 ± 2.07* |
IκBα expression in liver relative to GAPDH (3-h time point) | 0.35 ± 0.13 | 3.50 ± 0.88* |
IκBα expression in liver relative to GAPDH (6-h time point) | 0.72 ± 0.28 | 2.36 ± 0.26* |
Total cytochrome P450 in nmol/mg protein (24-h time point) | 0.578 ± 0.043 | 0.400 ± 0.083* |
CYP1A1/2 activity in pmol/mg protein/min as measured by EROD assay (24-h time point) | 123.84 ± 40.22 | 71.58 ± 12.52* |
CYP2B1/2 activity in pmol/mg protein/min as measured by PROD assay (24-h time point) | 8.62 ± 3.61 | 4.51 ± 0.50* |