Effect of (+)-kawain and individual kavalactones on P-glycoprotein ATPase activity
Treatment | ATPase Activity |
|---|---|
| nmol Pi/mg protein/min | |
| (+)-Kawain | |
| Control (MeOH) | 0.20 ± 0.12 |
| 87 nM | 3.35 ± 0.00 |
| 0.87 μM | 4.09 ± 1.04 |
| 8.7 μM | 6.14 ± 0.08 |
| Verapamil (positive control)a | 29.4 ± 4.1 |
| Kavalactones | |
| Control (MeOH) | 1.41 |
| Dihydrokawain (8.6 μM) | N.D. |
| Desmethoxyyangonin (8.8 μM) | 2.97 ± 4.19 |
| Yangonin (7.8 μM) | 1.17 ± 4.65 |
| Kavab | 1.73 ± 1.00 |
| Verapamil (positive control)a (20 μM) | 29.6 ± 2.0 |