TABLE 3

Disposition of radioactivity 72 h after an oral dose of [14C]kawain (100 mg/kg) to male F-344 Rats (n = 4): cumulative excretion of radioactivity


End of Collection Period

Percentage of Dose Recovered in

Total
Urine
Feces
8 h 31.1 ± 5.3 31.1 ± 5.3
24 h 62.2 ± 4.7 6.9 ± 3.9 69.1 ± 6.7
48 h 71.1 ± 2.9 13.1 ± 2.7 84.2 ± 3.0
72 h
76.8 ± 1.2
13.8 ± 2.7
90.6 ± 2.5