Disposition of radioactivity 72 h after an oral dose of [14C]kawain (100 mg/kg) to male F-344 Rats (n = 4): distribution in tissues
Tissue | Kawain | Tissue/Blood Ratio | Percentage of Dose in Total Tissue |
|---|---|---|---|
| ng-Eq/g tissue | |||
| Adipose | 439 ± 363 | 0.390 ± 0.379 | 0.0417 ± 0.0358 |
| Blood | 1240 ± 243 | Unity | 0.0810 ± 0.0136 |
| Brain | 38.8 ± 4.7 | 0.0317 ± 0.0039 | 0.0003 ± 0.0000 |
| Heart | 309 ± 30.5 | 0.253 ± 0.038 | 0.0009 ± 0.0001 |
| Kidney | 2370 ± 153 | 1.95 ± 0.35 | 0.0175 ± 0.0008 |
| Liver | 3150 ± 266 | 2.58 ± 0.42 | 0.129 ± 0.006 |
| Lung | 497 ± 34 | 0.408 ± 0.061 | 0.0018 ± 0.0001 |
| Muscle | 121 ± 15 | 0.101 ± 0.028 | 0.0432 ± 0.0065 |
| Skin | 622 ± 155 | 0.505 ± 0.132 | 0.104 ± 0.026 |
| Total in tissues |
|
| 0.420 ± 0.0590 |