Diazepam metabolic activities of CYP2D isoforms
The concentration of substrate (diazepam) was 50 μM. Other experimental details are described under Materials and Methods.
Activities | |||||
|---|---|---|---|---|---|
| p-Hydroxylation | 3-Hydroxylation | N-Desmethylation | |||
| nmol/min/nmol P450 | |||||
| CYP2D1 | N.D. | N.D. | 0.02 | ||
| CYP2D2 | N.D. | N.D. | N.D. | ||
| CYP2D3 | 1.19 | N.D. | 0.29 | ||
| CYP2D4 | N.D. | N.D. | 0.89 | ||
N.D., not detectable.