Cross-species circulating metabolite profiles
Metabolite Profile (% of Plasma 14C) | |||
|---|---|---|---|
| Rata | Monkeyb | ||
| Compound 1 | 78.5 | 37.4 | |
| M1 (hydroxylated 1) | 5.2 | 9.6 | |
| M2 (hydroxylated 1) | 3.2 | ||
| M3 (hydroxylated 1) | 2.7 | 17.4 | |
| Compound 2 | 1.6 | 13.5 | |
| M4 (hydroxylated 2) | |||
| Compound 3 | 10.3 | ||
| M5 (hydroxylated 3) | |||
| M6 (hydroxylated 3) | |||
| M7 (carbamic acid) | 5.6 | ||
| M8 (N-carbamoyl glucuronide) | |||
| % of 14C Profiled | 96.8 | 88.2 | |
↵ a Plasma from blood samples drawn at 2, 4, and 8 h postdose, which constituted >80% of the total 14C AUC0-12, was pooled by time point and analyzed individually to determine the percentage of total 14C AUC0-8 comprised by each compound.
↵ b The 2-h postdose sample (ca. total 14C Tmax) from each animal was combined within genders and the pool was analyzed.