Formation of TAM-DNA adducts via O-sulfonation of α-hydroxylated TAM and its metabolites using rat liver cytosol
DNA Adducts (Adducts/107 Nucleotides) | |||||||
|---|---|---|---|---|---|---|---|
| trans-Form | cis-Form fr-3 & 4 | Total | |||||
| fr-1 | fr-2 | ||||||
| α-OHTAM | 11.8 ± 2.7 | 85.0 ± 12.5 | 6.5 ± 1.6 | 103.3 ± 14.5 | |||
| α-OH-N-desTAM | 6.0 ± 2.8 | 42.8 ± 17.0 | 3.6 ± 1.9 | 52.4 ± 22.5 | |||
| α-OHTAM N-oxide | N.D. | 2.9 ± 0.4 | N.D. | 2.9 ± 0.4 | |||
Data are expressed as mean values ± S.D. from three analyses. N.D., not detectable.