P450 Isoform-Substrate (Reported Km Values) | Human Liver Microsomes | Supersomes | RAFa | ||||
---|---|---|---|---|---|---|---|
Km | Vmax
b
| Km | Vmax
b
| ||||
μM | μM | ||||||
CYP1A2-Phenacetin (30 μM) | 20.0 | 1.79 | 15.8 | 2.25 | 0.63 | ||
CYP2C9-Tolbutamide (400 μM) | 317 | 0.10 | 113 | 0.04 | 0.75 | ||
CYP2C19-S-Mephenytoin (60 μM) | 32.4 | 0.05 | 33.5 | 0.13 | 0.41 | ||
CYP2D6-Dextromethorphan (5 μM) | 6.56 | 2.02 | 2.50 | 3.82 | 0.20 | ||
CYP3A4-Testosterone (47 μM) | 46.6 | 1.64 | 28.5 | 1.74 | 0.58 |