Compound | Brain/Plasma | CSF/Plasma | CSF/Brain | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FVB | KO | KO/WT | FVB | KO | KO/WT | FVB | KO | KO/WT | |||||||
Buspirone | 1.6 | 2.0 | 1.3* | 0.051 | 0.038 | 0.75 | 0.031 | 0.019 | 0.61 | ||||||
Caffeine | 1.0 | 1.1 | 1.1* | 0.079 | 0.12 | 1.5 | 0.082 | 0.10 | 1.2 | ||||||
Carbamazepine | 0.76 | 0.81 | 1.1* | 0.35 | 0.38 | 1.1 | 0.46 | 0.47 | 1.0 | ||||||
Carisoprodol | 0.66 | 0.81 | 1.2 | 0.28 | 0.36 | 1.3* | 0.43 | 0.45 | 1.0 | ||||||
Chlorpromazine | 23 | 29 | 1.3* | 0.025 | 0.012 | 0.48 | 0.0011 | 0.00043 | 0.39 | ||||||
Citalopram | 5.1 | 9.7 | 1.9* | 0.53 | 0.77 | 1.5* | 0.10 | 0.079 | 0.79 | ||||||
Clozapine | 4.1 | 6.6 | 1.6* | 0.075 | 0.091 | 1.2* | 0.018 | 0.014 | 0.78 | ||||||
Cyclobenzaprine | 12 | 16 | 1.4* | 0.057 | 0.091 | 1.6* | 0.0049 | 0.0058 | 1.2 | ||||||
Diazepam | 2.0 | 2.3 | 1.2* | 0.066 | 0.059 | 0.89 | 0.034 | 0.025 | 0.74 | ||||||
Ethosuximide | 1.1 | 1.1 | 1.0 | 1.6 | 1.6 | 1.0 | 1.4 | 1.5 | 1.1 | ||||||
Fluoxetine | 12 | 18 | 1.5* | 0.031 | 0.040 | 1.3* | 0.0027 | 0.0022 | 0.81 | ||||||
Fluvoxamine | 6.1 | 14 | 2.3** | 0.058 | 0.093 | 1.6* | 0.010 | 0.0068 | 0.72 | ||||||
Haloperidol | 13 | 18 | 1.4* | 0.14 | 0.18 | 1.3* | 0.011 | 0.010 | 0.91 | ||||||
Hydrocodone | 2.1 | 4.5 | 2.1* | 0.56 | 1.0 | 1.8* | 0.27 | 0.22 | 0.81 | ||||||
Hydroxyzine | 7.7 | 7.6 | 1.0 | 0.073 | 0.067 | 0.92 | 0.0095 | 0.0089 | 0.94 | ||||||
Lamotrigine | 1.1 | 1.1 | 1.0 | 0.15 | 0.13 | 0.87 | 0.14 | 0.13 | 0.93 | ||||||
Meprobamatea | 0.42 | 0.70 | 1.7* | 0.39 | 1.2 | 3.1* | 0.93 | 1.8 | 1.9 | ||||||
Methylphenidate | 12 | 19 | 1.6* | 1.1 | 1.5 | 1.4* | 0.090 | 0.078 | 0.87 | ||||||
Metoclopramide | 1.2 | 7.9 | 6.6** | 0.44 | 1.2 | 2.7** | 0.36 | 0.15 | 0.42 | ||||||
Midazolam | 0.23 | 0.24 | 1.0 | 0.056 | 0.081 | 1.4 | 0.25 | 0.33 | 1.3 | ||||||
Morphine | 0.46 | 0.76 | 1.7* | 0.64 | 0.78 | 1.2* | 1.4 | 1.0 | 0.71 | ||||||
Nortriptyline | 11 | 20 | 1.8* | 0.024 | 0.036 | 1.5* | 0.0021 | 0.0017 | 0.81 | ||||||
Paroxetine | 3.3 | 7.1 | 2.2* | 0.015 | 0.025 | 1.7* | 0.0044 | 0.0035 | 0.80 | ||||||
Phenytoin | 0.63 | 0.78 | 1.2* | 0.18 | 0.18 | 1.0 | 0.28 | 0.24 | 0.86 | ||||||
Propoxyphene | 2.9 | 7.6 | 2.6** | 0.20 | 0.34 | 1.7* | 0.070 | 0.046 | 0.66 | ||||||
Risperidone | 0.78 | 8.0 | 10** | 0.019 | 0.12 | 6.3** | 0.025 | 0.015 | 0.60 | ||||||
9-OH-Risperidone | 0.060 | 1.0 | 17** | 0.045 | 0.42 | 9.3** | 0.74 | 0.42 | 0.57 | ||||||
Selegiline | 3.7 | 4.1 | 1.1* | 0.44 | 0.42 | 1.0 | 0.12 | 0.10 | 0.83 | ||||||
Sertraline | 24 | 27 | 1.1 | N.D. | N.D. | N.D. | N.D. | ||||||||
Sulpiride | 0.078 | 0.15 | 1.9* | 0.038 | 0.073 | 1.9 | 0.48 | 0.48 | 1.0 | ||||||
Thiopental | 0.36 | 0.44 | 1.2* | 0.046 | 0.065 | 1.4* | 0.13 | 0.15 | 1.2* | ||||||
Trazodone | 0.61 | 0.54 | 0.89 | 0.037 | 0.043 | 1.2 | 0.061 | 0.079 | 1.3* | ||||||
Venlafaxine | 4.2 | 7.7 | 1.8* | 0.41 | 0.74 | 1.8* | 0.099 | 0.096 | 0.97 | ||||||
Zolpidem | 0.29 | 0.40 | 1.4* | 0.37 | 0.44 | 1.2 | 1.3 | 1.1 | 0.85 |