fuplasma/fubrain | [Brain]/[Plasma] | fubrain | [CSF]/[Brain] | fuplasma | [CSF]/[Plasma] | |
---|---|---|---|---|---|---|
Buspirone | 1.24 ± 0.06 | 1.6 | 0.22 ± 0.02 | 0.031 | 0.273 ± 0.018 | 0.051 |
Caffeine | 2.2 ± 0.2 | 1.0 | 0.52 ± 0.12 | 0.082 | 1.13 ± 0.03 | 0.079 |
Carbamazepine | 2.79 ± 0.09 | 0.76 | 0.116 ± 0.0081 | 0.46 | 0.324 ± 0.014 | 0.35 |
Carisoprodol | 1.93 ± 0.06 | 0.66 | 0.202 ± 0.015 | 0.43 | 0.389 ± 0.003 | 0.28 |
Chlorpromazine | 47 ± 8 | 23 | 0.00076 ± 0.00018 | 0.0011 | 0.0354 ± 0.0119 | 0.025 |
Citalopram | 7.6 ± 0.3 | 5.1 | 0.0306 ± 0.0018 | 0.10 | 0.231 ± 0.013 | 0.53 |
Clozapine | 4.0 ± 0.2 | 4.1 | 0.0094 ± 0.0013 | 0.018 | 0.038 ± 0.002 | 0.075 |
Cyclobenzaprine | 7.4 ± 0.4 | 12 | 0.0073 ± 0.0004 | 0.0049 | 0.054 ± 0.006 | 0.057 |
Diazepam | 1.96 ± 0.07 | 2.0 | 0.050 ± 0.003 | 0.034 | 0.098 ± 0.007 | 0.066 |
Fluoxetine | 13.5 ± 1.2 | 12 | 0.0023 ± 0.0005 | 0.0027 | 0.031 ± 0.002 | 0.031 |
Fluvoxamine | 4.6 ± 0.2 | 6.1 | 0.0084 ± 0.0008 | 0.01 | 0.0387 ± 0.0019 | 0.058 |
Haloperidol | 12.3 ± 1.3 | 13 | 0.0071 ± 0.0017 | 0.011 | 0.087 ± 0.009 | 0.14 |
Hydrocodone | 1.07 ± 0.06 | 2.1 | 0.55 ± 0.06 | 0.27 | 0.59 ± 0.04 | 0.56 |
Hydroxyzine | 5.1 ± 0.3 | 7.7 | 0.0102 ± 0.0012 | 0.0095 | 0.052 ± 0.005 | 0.073 |
Lamotrigine | 1.73 ± 0.16 | 1.1 | 0.22 ± 0.04 | 0.14 | 0.38 ± 0.05 | 0.15 |
Meprobamate | 1.00 ± 0.05 | 0.42 | 0.76 ± 0.04 | 0.93 | 0.76 ± 0.08 | 0.39 |
Methylphenidate | 3.50 ± 0.14 | 12 | 0.220 ± 0.006 | 0.090 | 0.77 ± 0.07 | 1.1 |
Metocloperamide | 2.29 ± 0.16 | 1.2 | 0.31 ± 0.05 | 0.36 | 0.71 ± 0.03 | 0.44 |
Midazolam | 1.69 ± 0.08 | 0.23 | 0.0272 ± 0.0018 | 0.25 | 0.046 ± 0.004 | 0.056 |
Morphine | 0.64 ± 0.04 | 0.46 | 0.50 ± 0.07 | 1.4 | 0.32 ± 0.03 | 0.64 |
Nortriptylinea | 6.7 ± 0.9 | 11 | 0.0046 ± 0.0006 | 0.0021 | 0.031 ± 0.009 | 0.024 |
Paroxetine | 3.8 ± 0.3 | 3.3 | 0.0039 ± 0.0002 | 0.0044 | 0.015 ± 0.003 | 0.015 |
Phenytoin | 2.26 ± 0.05 | 0.63 | 0.081 ± 0.004 | 0.28 | 0.183 ± 0.006 | 0.18 |
Propoxyphene | 3.4 ± 0.3 | 2.9 | 0.033 ± 0.006 | 0.070 | 0.111 ± 0.005 | 0.20 |
Risperidone | 3.04 ± 0.15 | 0.78 | 0.067 ± 0.007 | 0.025 | 0.204 ± 0.011 | 0.019 |
9-OH-Risperidone | 3.84 ± 0.17 | 0.06 | 0.086 ± 0.004 | 0.74 | 0.33 ± 0.03 | 0.045 |
Selegiline | 2.86 ± 0.10 | 3.7 | 0.056 ± 0.004 | 0.12 | 0.160 ± 0.008 | 0.44 |
Sertraline | 16.7 ± 1.8 | 24 | 0.00066 ± 0.00012 | 0.00020b | 0.011 ± 0.002 | 0.0058b |
Sulpiride | 1.21 ± 0.09 | 0.078 | 0.63 ± 0.10 | 0.48 | 0.76 ± 0.05 | 0.038 |
Thiopentalc | 2.078 ± 0.006 | 0.36 | 0.14630 ± 0.00010 | 0.13 | 0.304 ± 0.002 | 0.046 |
Trazodone | 1.09 ± 0.10 | 0.61 | 0.047 ± 0.009 | 0.061 | 0.051 ± 0.007 | 0.037 |
Venlafaxinec | 4.3 ± 0.4 | 4.2 | 0.21 ± 0.03 | 0.099 | 0.90 ± 0.13 | 0.41 |
Zolpidema | 1.20 ± 0.08 | 0.29 | 0.20 ± 0.03 | 1.3 | 0.24 ± 0.02 | 0.37 |