TABLE 2

Estimation of the influx (CL_influx), efflux (CL_efflux), metabolic intrinsic clearance (CL_int,met), and excretory intrinsic clearance (CL_int,sec) consistent with the clearances observed for the single-pass perfused rat liver preparation ^a

	Observed	Predicted by Sirianni and Pang (1997)	New and Improved Predictions
Hepatic metabolic clearance CL_liver,met (ml/min/g)	0.345^a	0.348	0.345
Biliary clearance CL_liver,ex (ml/min/g)	0.022^a	0.017	0.022
Total hepatic clearance CL_liver,tot (ml/min/g)	0.366^a	0.365	0.367
Observed C_T,ss/C_P,ss	1.5 to 19^b
CL_liver,met/CL_liver,ex	15.7^a	20.1	15.7
CL_int,met/CL_int,sec	15.7^c	20.1	15.7
CL_influx (ml/min/g)		2.13	4.00^d
CL_efflux (ml/min/g)		2.13	1.46
CL_int,met (ml/min/g)		2.72	0.61^d
CL_int,sec (ml/min/g)		0.135	0.039
Calculated C_T,ss,u/C_P,ss,u^e		0.43	1.9
CL_influx/CL_int,met	6.56^d	0.78^f	6.56^c
CL_influx/CL_efflux		1.00	2.7

↵ a Based on data of deLannoy et al. (1993).
↵ b Observed by Pang et al. (1991).
↵ c Based on equations.
↵ d In vitro hepatocyte data of Abu-Zahra et al. (2000) and Abu-Zahra and Pang (2000) (from Table 2).
↵ e CL_influx/(CL_efflux + CL_int,met + CL_int,sec).
↵ f Did not agree with observations of Abu-Zahra et al. (2000) and Abu-Zahra and Pang (2000).