Observed | Predicted by Sirianni and Pang (1997) | New and Improved Predictions | |
---|---|---|---|
Hepatic metabolic clearance CLliver,met (ml/min/g) | 0.345a | 0.348 | 0.345 |
Biliary clearance CLliver,ex (ml/min/g) | 0.022a | 0.017 | 0.022 |
Total hepatic clearance CLliver,tot (ml/min/g) | 0.366a | 0.365 | 0.367 |
Observed CT,ss/CP,ss | 1.5 to 19b | ||
CLliver,met/CLliver,ex | 15.7a | 20.1 | 15.7 |
CLint,met/CLint,sec | 15.7c | 20.1 | 15.7 |
CLinflux (ml/min/g) | 2.13 | 4.00d | |
CLefflux (ml/min/g) | 2.13 | 1.46 | |
CLint,met (ml/min/g) | 2.72 | 0.61d | |
CLint,sec (ml/min/g) | 0.135 | 0.039 | |
Calculated CT,ss,u/CP,ss,ue | 0.43 | 1.9 | |
CLinflux/CLint,met | 6.56d | 0.78f | 6.56c |
CLinflux/CLefflux |
| 1.00 | 2.7 |