TABLE 4

Simulations of hepatic metabolic, biliary, and total clearances, based on changes in secretion and metabolism intrinsic clearances, and the efflux and influx clearances

Parameters
Predicted Changes
No Secretion: EHBR
No Metabolism
Decreased Efflux
Decreased Influx
CLinflux (ml/min/g) 4.00 Same Same Same ↓ 50%
CLefflux (ml/min/g) 1.46 Same Same ↓ 50% Same
CLint,met (ml/min/g) 0.61 Same 0 Same Same
CLint,sec (ml/min/g) 0.0388 0 Same Same Same
Hepatic metabolic clearance CLliver,met (ml/min/g) 0.345 0.358a 0 0.424 0.224
Biliary clearance CLliver,ex (ml/min/g) 0.022 0 0.053a 0.027 0.014
Total hepatic clearance CLliver,tot (ml/min/g) 0.367 0.358 0.053 0.451 0.238
CLliver,met/CLliver,ex 15.7 15.7 15.7
CLint,met/CLint,sec 15.7 15.7 15.7
Calculated CT,ss/CP,ssa 1.9 1.93 2.67 2.90 0.95
CLinflux/CLint,met 6.56 6.56 6.56 3.28
CLinflux/CLefflux
2.74
2.74
2.74
5.48
1.37

  • ↵ a fPCLinflux/[fL(CLefflux + CLint,met + CLint,sec)].