Parameters | Predicted Changes | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Increased Secretion Example 1 | Increased Metabolism Example 2 | Decreased Secretion Example 3 | Decreased Metabolism Example 4 | Decreased Secretion; Decreased Efflux Example 5 | Decreased Secretion; Decreased Efflux Example 6 | |||||||
CLinflux (ml/min/g) | 4.00 | Same | Same | Same | Same | Same | Same | |||||
CLefflux (ml/min/g) | 1.46 | Same | Same | Same | Same | 50% | 90% | |||||
CLint,met (ml/min/g) | 0.61 | Same | 200% | Same | 50% | Same | Same | |||||
CLint,sec (ml/min/g) | 0.0388 | 500% | Same | 50% | Same | 50% | 10% | |||||
Hepatic metabolic clearance CLliver,met (ml/min/g) | 0.345 | 0.300 (↓) | 0.434 (↑) | 0.351 (↑) | 0.244 (↓) | 0.434 (↑) | 0.523 (↑) | |||||
Biliary clearance CLliver,ex (ml/min/g) | 0.022 | 0.095 (↑) | 0.014 (↓) | 0.011 (↓) | 0.031 (↑) | 0.014 (↓) | 0.030 (↑) | |||||
Total hepatic clearance CLliver,tot (ml/min/g) | 0.367 | 0.395 (↑) | 0.448 (↑) | 0.362 (↓) | 0.275 (↓) | 0.448 (↑) | 0.553 (↑) | |||||
CLliver,met/CLliver,ex = CLint,met/CLint,sec | 15.7 | 3.1 | 31.4 | 31.4 | 7.9 | 31.4 | 17.4 | |||||
Calculated CT,ss/CP,ssa | 1.9 | 1.77 | 1.47 | 1.91 | 2.22 | 2.94 | 5.06 |
↵ a fPCLinflux/[fL(CLefflux + CLint,met + CLint,sec)].