Description | Symbol | Assigned Values |
---|---|---|

Doses (μmol/200 ml) | Dose | 10 and 100 |

Compartment volumes (ml/g) | ||

Reservoir plasma |
V
_{R}
| 20 |

Hepatic plasma |
V
_{PL}
| 0.128 |

Hepatic tissue water |
V
_{L}
| 0.6 |

Canalicular bile |
V
_{bile}
| 0.004 |

Flow rates (ml/min/g) | ||

Hepatic plasma |
Q
_{L}
| 0.8 |

Bile |
Q
_{bile}
| 0.001 |

Clearances for hypothetical drug (ml/min/g) | ||

Biliary intrinsic clearance | CL_{int, sec} | 0.1 (to 0.5, 0.25, and 0.05) |

Basolateral influx clearance | CL_{influx} | 4 (to 8, 1, and 0.5) |

Basolateral efflux clearance | CL_{efflux} | 2 (to 4, 1, and 0.5) |

Nonlinear metabolism - Michaelis-Menten parameters | ||

Maximum velocity (nmol/min/g) |
V
_{max}
| 5 |

Michaelis-Menten constant (μM) |
K
_{m}
| 20 |

Fractions unbound for drug | ||

Plasma |
f
_{P}
| 0.55 |

Tissue |
f
_{L}
| 0.55 |