TABLE 8

Literature values of area under the curve (AUC) and clearances (CL) after intravenous administrations to wild-type [mdr1a(+/+)] and Pgp-knockout [mdr1a(-/-)] mice



AUC

CL

Reference

mdr1a (+/+)
mdr1a (-/-)
mdr1a (+/+)
mdr1a (-/-)
ng/ml ยท h l/h/kg
Vinblastine
1 mg/kg 99 157 10.1 6.4 Van Asperen et al. (1996)
6 mg/kg 1015 1470 5.9 4.3
Paclitaxel (10 mg/kg) 4.45 9.1 2.24 1.10 Spareboom et al. (1997)
FK506 (2 mg/kg) 563 1323 3.35 1.16 Yokogawa et al. (1999)
Digoxin (1 mg/kg)
2590
7330
0.065
0.029
Kawahara et al. (1999)