AUC | CL | Reference | |||||
---|---|---|---|---|---|---|---|
mdr1a (+/+) | mdr1a (-/-) | mdr1a (+/+) | mdr1a (-/-) | ||||
ng/ml ยท h | l/h/kg | ||||||
Vinblastine | |||||||
1 mg/kg | 99 | 157 | 10.1 | 6.4 | Van Asperen et al. (1996) | ||
6 mg/kg | 1015 | 1470 | 5.9 | 4.3 | |||
Paclitaxel (10 mg/kg) | 4.45 | 9.1 | 2.24 | 1.10 | Spareboom et al. (1997) | ||
FK506 (2 mg/kg) | 563 | 1323 | 3.35 | 1.16 | Yokogawa et al. (1999) | ||
Digoxin (1 mg/kg) | 2590 | 7330 | 0.065 | 0.029 | Kawahara et al. (1999) |