Inhibitors | Biliary Clearance (ml/min) | Metabolism or Metabolic Clearance (ml/min) | AUC | CLliver,tot (ml/min) | Reference |
---|---|---|---|---|---|
FK506 (100 μg) | |||||
+ Troleandomycin (Cyp3a inhibitor) | Not measured | Not measured | Increaseda | Decreaseda | Wu and Benet (2003) |
+ GG918 (P-glycoprotein inhibitor) | Not measured | Not measured | Decreasedb | Increasedb | |
+ Cyclosporine (Cyp3a and P-glycoprotein inhibitor) | Not measured | Not measured | Increaseda | Decreaseda | |
Digoxin (10 μg) | |||||
+ Rifampicin 100 μM (Oatp2 inhibitor) | Not measured | Decreaseda | Increaseda | Decreaseda | Lau et al. (2004) |
+ Quinidine 10 μM (P-glycoprotein inhibitor) | Not measured | Increaseda | Decreasedb | Increasedb |
|