Kinetic constants for glucuronide and glucoside formation by pooled human liver (HLM), kidney (HKM), and intestinal microsomes (HIM)
Results are means of duplicate measurements.
Km | Vmax | CLint | |
|---|---|---|---|
| mM | nmol/mg/min | μl/mg/min | |
| Human liver microsomes | |||
| MPAG | 0.18 | 5.16 | 28.70 |
| AcMPAG | 0.37 | 0.14 | 0.38 |
| MPAGls | 0.07 | 0.45 | 6.40 |
| AcMPAGls | 0.06 | 0.01 | 0.15 |
| Human kidney microsomes | |||
| MPAG | 0.57 | 12.94 | 22.62 |
| AcMPAG | 0.36 | 0.04 | 0.12 |
| MPAGls | 0.07 | 0.38 | 5.57 |
| AcMPAGls | 0.83 | 0.02 | 0.02 |
| Human intestinal microsomes | |||
| MPAG | 1.03 | 0.71 | 0.69 |
| AcMPAG | 1.17 | 0.01 | 0.01 |
| MPAGls | 1.42 | 0.02 | 0.01 |
| AcMPAGls |
| L.A. |
|
L.A., low activity.