Kinetic parameters of genistein glucuronidation in different microsomes
Parameters | Duodenum | Jejunum | Ileum | Colon | Liver |
|---|---|---|---|---|---|
| Vmax1 (nmol /min/mg) | 1.445 | 3.171 | 1.423 | 0.435 | 3.713 |
| Km1 (μM) | 4.04 | 6.628 | 8.239 | 3.186 | 23.6 |
| Vmax1/Km1 (ml/min/mg) | 0.357 | 0.478 | 0.172 | 0.136 | 0.157 |
| Vmax2 (biphasic) (nmol/min/mg) | 0.041 | 1.59E3 | 0.826 | ||
| Km2 (μM) | 7.994 | 2.74E5 | 0.71E-7 | ||
| R 2 | 0.998 | 0.995 | 0.963 | 0.995 | 0.989 |
| AIC | -55.67 | -19.13 | -21.85 | -53.61 | -17.9 |